CYP11B1

Across TCGA patient cohorts, CYP11B1 mutation is significantly associated with the RNA expression of many other genes, with 4,098 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CYP11B1-associated genes across cancer lineages are RAN, NCAPG, and CCT8. Each is linked with CYP11B1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CYP11B1-to-partner and partner-to-CYP11B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAN grouped by CYP11B1-low versus CYP11B1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP11B1→partner) and Y-score (partner→CYP11B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RAN →	+0.453	+3.593	.002	.001	3	5
SKCM	NCAPG →	+0.703	+2.528	<.001	<.001	3	5
UCEC	CCT8 →	+0.350	+1.856	.006	.004	3	5
UCEC	TIPIN →	+0.432	+2.332	<.001	.003	3	5
SKCM	MAD2L1 →	+0.546	+2.353	.002	<.001	3	5
SKCM	PDHX →	+0.454	+2.267	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,098 associations by consensus.

RAN by CYP11B1 expression — LUAD

Explore this box plot interactively →