CYP11B1

Across TCGA patient cohorts, CYP11B1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP11B1-associated genes across cancer lineages are ASNS, Chk2, and GAPDH. Each is linked with CYP11B1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP11B1-to-partner and partner-to-CYP11B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CYP11B1-low versus CYP11B1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP11B1→partner) and Y-score (partner→CYP11B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.651	+1.874	<.001	.049	3	4
LUAD	Chk2 →	+0.219	+1.700	.032	.043	3	4
LUAD	GAPDH →	+0.472	+3.000	.027	.034	3	3
UCEC	PDCD4 →	-0.662	-2.807	<.001	.002	3	3
LUAD	Src_pY527 →	-0.329	-2.222	.030	.010	3	3
LUAD	STAT3_pY705 →	-0.352	-2.459	.001	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ASNS by CYP11B1 expression — LUAD

Explore this box plot interactively →