CYP11B1

Across TCGA cell cohorts, CYP11B1 mutation is significantly associated with the RNA expression of many other genes, with 107 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP11B1-associated genes across cancer lineages are ELOA3DP, ASCL3, and SMCP. Each is linked with CYP11B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP11B1-to-partner and partner-to-CYP11B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by CYP11B1-low versus CYP11B1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP11B1→partner) and Y-score (partner→CYP11B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3DP →	+0.018	+2.688	<.001	.002	3	3
LARGE_INTESTINE	ASCL3 →	+0.186	+2.404	<.001	.009	3	2
CNS	SMCP →	+0.136	+4.321	<.001	.009	3	1
CNS	LCE3E →	+0.301	+4.754	<.001	.005	3	1
BLOOD_Leukemia	DKK4 →	+0.160	+3.971	.006	.002	3	1
BLOOD_Leukemia	TNP1 →	+0.111	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

ELOA3DP by CYP11B1 expression — LARGE_INTESTINE

Explore this box plot interactively →