CYP11A1

Across TCGA patient cohorts, CYP11A1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,086 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CYP11A1-associated genes across cancer lineages are DMC1, TIMP3, and MCM5. Each is linked with CYP11A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP11A1-to-partner and partner-to-CYP11A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP11A1 versus DMC1 in OV, with a Pearson correlation of -0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP11A1→partner) and Y-score (partner→CYP11A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DMC1 →	-1.397	-2.829	<.001	.002	3	1
OV	TIMP3 →	-2.399	-2.492	<.001	.006	3	1
OV	MCM5 →	-0.901	-1.721	.001	.006	3	1
OV	CDKN3 →	-1.964	-3.083	.001	.001	3	1
OV	MYLK2 →	-0.665	-1.725	.001	.005	3	1
OV	FAM83D →	-1.275	-1.851	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,086 associations by consensus.

CYP11A1 vs DMC1 — OV

Explore this scatter interactively →