CYP11A1

Across TCGA patient cohorts, CYP11A1 mutation is significantly associated with the RNA expression of many other genes, with 4,167 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP11A1-associated genes across cancer lineages are RMC1, ZWILCH, and TOE1. Each is linked with CYP11A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP11A1-to-partner and partner-to-CYP11A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RMC1 grouped by CYP11A1-low versus CYP11A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP11A1→partner) and Y-score (partner→CYP11A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RMC1 →	+0.352	+3.353	<.001	<.001	3	4
UCEC	ZWILCH →	+0.614	+2.488	<.001	<.001	3	4
SKCM	TOE1 →	+0.339	+2.919	.001	<.001	3	4
UCEC	MAPK1 →	+0.575	+3.202	<.001	<.001	3	3
UCEC	SRRD →	+0.419	+2.177	<.001	<.001	3	3
UCEC	RANBP9 →	+0.344	+2.558	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,167 associations by consensus.

RMC1 by CYP11A1 expression — UCEC

Explore this box plot interactively →