CYP11A1

Across TCGA patient cohorts, CYP11A1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP11A1-associated genes across cancer lineages are Src, ASNS, and Cyclin-B1. Each is linked with CYP11A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP11A1-to-partner and partner-to-CYP11A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src grouped by CYP11A1-low versus CYP11A1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP11A1→partner) and Y-score (partner→CYP11A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Src →	-0.240	-2.115	.016	.018	3	3
UCEC	ASNS →	+0.359	+1.584	.003	.034	3	3
UCEC	Cyclin-B1 →	+0.593	+2.201	.001	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.176	-2.906	.001	.001	3	2
UCEC	Ku80 →	+0.225	+1.598	.004	.006	3	2
UCEC	MEK1 →	+0.437	+2.247	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Src by CYP11A1 expression — SKCM

Explore this box plot interactively →