CYP11A1

Across TCGA cell cohorts, CYP11A1 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP11A1-associated genes across cancer lineages are NXF5, GSTA5, and C9orf92. Each is linked with CYP11A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP11A1-to-partner and partner-to-CYP11A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXF5 grouped by CYP11A1-low versus CYP11A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP11A1→partner) and Y-score (partner→CYP11A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NXF5 →	+0.159	+3.787	<.001	.004	3	2
SOFT_TISSUE	GSTA5 →	+0.035	+4.930	<.001	.008	3	1
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
LARGE_INTESTINE	KRTAP10-1 →	+0.013	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR5V1 →	+0.013	+6.022	<.001	.001	3	1
BREAST	C7orf33 →	+0.209	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

NXF5 by CYP11A1 expression — BLOOD_Leukemia

Explore this box plot interactively →