CYP11A1

Across TCGA cell cohorts, CYP11A1 mutation is significantly associated with the mutation status of many other genes, with 2,968 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP11A1-associated genes across cancer lineages are ZNF197, MAP4, and NCAPH. Each is linked with CYP11A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP11A1-to-partner and partner-to-CYP11A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF197 grouped by CYP11A1-low versus CYP11A1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP11A1→partner) and Y-score (partner→CYP11A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF197 →	+4.187	+5.000	.008	.008	1	4
LUNG_NSCLC_LUAD	MAP4 →	+4.187	+5.000	.008	.008	1	4
BLOOD_Leukemia	NCAPH →	+4.845	+4.285	<.001	<.001	1	4
BLOOD_Leukemia	ABCC11 →	+2.523	+2.960	.005	.005	1	4
SOFT_TISSUE	BTN1A1 →	+4.502	+5.066	.007	.007	1	4
SOFT_TISSUE	ATP2B3 →	+4.502	+5.066	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,968 associations by consensus.

ZNF197 by CYP11A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →