Across TCGA patient cohorts, CYLC1 mutation is significantly associated with the RNA expression of many other genes, with 3,714 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYLC1-associated genes across cancer lineages are NDC80, MBD2, and KNL1. Each is linked with CYLC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CYLC1-to-partner and partner-to-CYLC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLC1→partner) and Y-score (partner→CYLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NDC80 →	+0.837	+3.499	<.001	.002	3	5
UCEC	MBD2 →	+0.287	+1.279	.005	.003	3	4
UCEC	KNL1 →	+0.498	+2.042	<.001	.001	3	4
UCEC	CDK11B →	+0.298	+1.795	<.001	<.001	3	3
UCEC	CHEK1 →	+0.536	+1.724	<.001	.001	3	3
UCEC	BUB3 →	+0.433	+1.387	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,714 associations by consensus.

Exploration

CYLC1 survival (RNA) · tumor vs normal (RNA) · all CYLC1 data types