CYLC1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CYLC1 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYLC1-associated genes across cancer lineages are p27_pT157, EGFR_pY1068, and FASN. Each is linked with CYLC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYLC1-to-partner and partner-to-CYLC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLC1→partner) and Y-score (partner→CYLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMp27_pT157 →+0.110+1.353.001.01433
UCECEGFR_pY1068 →-0.235-2.070<.001.00132
UCECFASN →+0.367+2.201.001<.00132
COADJNK_pT183_Y185 →-0.310-2.982.008.03432
UCECNotch1 →+0.087+1.372.030.02232
COADp21 →+0.197+3.501.047.00232
Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

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