CYGB

Across TCGA patient cohorts, CYGB mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYGB-associated genes across cancer lineages are ATM, ACVRL1, and P-Cadherin. Each is linked with CYGB in more than 1 cancer types. Because this analysis shows association rather than direction, both CYGB-to-partner and partner-to-CYGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CYGB-low versus CYGB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYGB→partner) and Y-score (partner→CYGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.612	-3.169	.013	.020	3	1
UCEC	ACVRL1 →	-0.150	-2.980	.044	.036	2	1
UCEC	P-Cadherin →	-0.164	-3.156	.038	.020	2	1
UCEC	Shc_pY317 →	-0.228	-3.169	.006	.020	2	1
UCEC	A-Raf_pS299 →	-0.213	-3.169	.001	.020	1	1
UCEC	GATA6 →	-0.198	-3.162	.019	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ATM by CYGB expression — UCEC

Explore this box plot interactively →