CYGB

Across TCGA cell cohorts, CYGB mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYGB-associated genes across cancer lineages are KRT71, TMSB4Y, and IQCF5. Each is linked with CYGB in more than 1 cancer types. Because this analysis shows association rather than direction, both CYGB-to-partner and partner-to-CYGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT71 grouped by CYGB-low versus CYGB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYGB→partner) and Y-score (partner→CYGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRT71 →	+0.488	+3.520	.009	.005	3	1
LARGE_INTESTINE	TMSB4Y →	+1.049	+3.556	.004	.007	3	1
LARGE_INTESTINE	IQCF5 →	+0.021	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CFHR1 →	+0.098	+3.333	.004	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KRT71 by CYGB expression — LARGE_INTESTINE

Explore this box plot interactively →