CYFIP2

Across TCGA pan-cancer cohorts, CYFIP2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CYFIP2 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CYFIP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYFIP2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

UCEC, LUAD, and GBM are the cancer types where CYFIP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.806	1.000	.006	18	view →
LUAD	OS	Tertile	II,III,IV	0.868	0.310	.004	17	view →
GBM	DFS	Quartile	All	0.896	0.560	<.001	10	view →
HNSC	DFS	Quartile	II,III,IV	0.892	1.000	.014	6	view →
PDAC	DFS	Tertile	III,IV	0.825	0.406	.011	5	view →
CCRCC	DFS	Tertile	All	0.708	0.890	.038	4	view →
LSCC	DFS	Tertile	All	0.815	0.333	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CYFIP2–UCEC (DFS)

Open the UCEC breakdown →