CYFIP2

Across TCGA patient cohorts, CYFIP2 mutation is significantly associated with the RNA expression of many other genes, with 4,968 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYFIP2-associated genes across cancer lineages are NOM1, CDCA2, and WDHD1. Each is linked with CYFIP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CYFIP2-to-partner and partner-to-CYFIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOM1 grouped by CYFIP2-low versus CYFIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYFIP2→partner) and Y-score (partner→CYFIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOM1 →	+0.257	+1.277	.001	<.001	3	5
COAD	CDCA2 →	+0.704	+2.920	<.001	.001	3	5
SKCM	WDHD1 →	+0.524	+2.466	<.001	.001	3	5
SKCM	MYO19 →	+0.384	+1.616	<.001	.001	3	5
UCEC	ARMC7 →	+0.246	+1.109	.008	.007	3	4
UCEC	HAUS2 →	+0.436	+1.371	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,968 associations by consensus.

NOM1 by CYFIP2 expression — UCEC

Explore this box plot interactively →