CYFIP2

Across TCGA cell cohorts, CYFIP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,527 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYFIP2-associated GO terms across cancer lineages are Positive regulation of neurotrophin TRK receptor signaling pathway, Regulation of neurotrophin TRK receptor signaling pathway, and Dendrite extension. Each is linked with CYFIP2 in more than 11 cancer types. Because this analysis shows association rather than direction, both CYFIP2-to-partner and partner-to-CYFIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of neurotrophin TRK receptor signaling pathway grouped by CYFIP2-low versus CYFIP2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYFIP2→partner) and Y-score (partner→CYFIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of neurotrophin TRK receptor signaling pathway →	+0.230	+2.043	<.001	<.001	3	12
STOMACH	Regulation of neurotrophin TRK receptor signaling pathway →	+0.258	+2.372	<.001	.005	3	11
OVARY	Dendrite extension →	+0.128	+1.739	<.001	.005	3	10
LUNG_NSCLC_LUAD	Cell fate commitment →	-0.039	-1.280	.001	.001	3	9
BREAST	Positive regulation of oxidoreductase activity →	+0.207	+2.463	<.001	<.001	3	9
CNS	Cellular response to cell-matrix adhesion →	+0.173	+1.419	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,527 associations by consensus.

Positive regulation of neurotrophin TRK receptor signaling pathway by CYFIP2 expression — SOFT_TISSUE

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