CYFIP1

Across TCGA patient cohorts, CYFIP1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYFIP1-associated genes across cancer lineages are ATM, PCNA, and mTOR_pS2448. Each is linked with CYFIP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYFIP1-to-partner and partner-to-CYFIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CYFIP1-low versus CYFIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYFIP1→partner) and Y-score (partner→CYFIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.377	-2.308	.005	.005	3	4
COAD	PCNA →	+0.386	+2.820	.004	.035	3	3
UCEC	mTOR_pS2448 →	-0.102	-2.794	.022	.003	3	3
UCEC	PDCD4 →	-0.341	-1.430	.016	.022	3	3
UCEC	EGFR_pY1068 →	-0.172	-1.321	.023	.012	3	2
UCEC	eIF4E →	+0.147	+1.820	.021	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ATM by CYFIP1 expression — UCEC

Explore this box plot interactively →