CYFIP1

Across TCGA cell cohorts, CYFIP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,302 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CYFIP1-associated GO terms across cancer lineages are Regulation of translation at postsynapse, modulating synaptic transmission, Regulation of translation at postsynapse, and Positive regulation of lamellipodium assembly. Each is linked with CYFIP1 in more than 17 cancer types. Because this analysis shows association rather than direction, both CYFIP1-to-partner and partner-to-CYFIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translation at postsynapse, modulating synaptic transmission grouped by CYFIP1-low versus CYFIP1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYFIP1→partner) and Y-score (partner→CYFIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of translation at postsynapse, modulating synaptic transmission →	+0.179	+1.474	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Regulation of translation at postsynapse →	+0.181	+1.288	<.001	<.001	3	18
URINARY_TRACT	Positive regulation of lamellipodium assembly →	+0.107	+0.825	<.001	<.001	3	12
OVARY	Positive regulation of lamellipodium organization →	+0.077	+0.655	<.001	.003	3	11
SKIN	Regulation of lamellipodium assembly →	+0.109	+0.636	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.071	+0.839	<.001	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,302 associations by consensus.

Regulation of translation at postsynapse, modulating synaptic transmission by CYFIP1 expression — BLOOD_Leukemia

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