CYFIP1

Across TCGA cell cohorts, CYFIP1 mutation is significantly associated with the RNA expression of many other genes, with 1,744 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYFIP1-associated genes across cancer lineages are FBXO3, BBOF1, and TTI2. Each is linked with CYFIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYFIP1-to-partner and partner-to-CYFIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO3 grouped by CYFIP1-low versus CYFIP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYFIP1→partner) and Y-score (partner→CYFIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXO3 →	+0.552	+3.321	<.001	.002	3	2
LARGE_INTESTINE	BBOF1 →	+0.653	+2.043	.003	.008	3	2
LARGE_INTESTINE	TTI2 →	+0.686	+2.743	<.001	.001	3	2
LARGE_INTESTINE	PGBD1 →	+0.746	+2.743	<.001	.001	3	2
LARGE_INTESTINE	FNBP1L →	+0.539	+2.743	.006	.001	3	2
LARGE_INTESTINE	COPS4 →	+0.817	+3.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,744 associations by consensus.

FBXO3 by CYFIP1 expression — LARGE_INTESTINE

Explore this box plot interactively →