CYFIP1

Across TCGA cell cohorts, CYFIP1 mutation is significantly associated with the mutation status of many other genes, with 5,882 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYFIP1-associated genes across cancer lineages are MBD5, TCF20, and PPL. Each is linked with CYFIP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CYFIP1-to-partner and partner-to-CYFIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD5 grouped by CYFIP1-low versus CYFIP1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYFIP1→partner) and Y-score (partner→CYFIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MBD5 →	+3.660	+3.193	.006	.006	1	5
LARGE_INTESTINE	TCF20 →	+1.807	+2.584	<.001	<.001	1	5
LARGE_INTESTINE	PPL →	+2.655	+2.413	<.001	<.001	1	5
LARGE_INTESTINE	TTC21B →	+3.222	+2.471	<.001	<.001	1	5
BLOOD_Lymphoma	DOCK4 →	+3.289	+2.731	.003	.003	1	5
LARGE_INTESTINE	ZMYM3 →	+2.614	+2.108	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,882 associations by consensus.

MBD5 by CYFIP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →