Across TCGA pan-cancer cohorts, CYCTP RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CYCTP’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CYCTP RNA is repressed in tumor relative to normal tissue. In most cancer types CYCTP is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC are the cancer types where CYCTP tumor–normal differential expression is most reproducible.