CYCSP53

Across TCGA pan-cancer cohorts, CYCSP53 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated CYCSP53 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CYCSP53 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CYCSP53 expression acts as an unfavorable survival marker.

CESC, READ, and ACC are the cancer types where CYCSP53 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.124	0.798	<.001	108	view →
READ	OS	Tertile	All	0.173	0.828	<.001	108	view →
ACC	DFS	Tertile	All	0.046	0.753	<.001	108	view →
ESCA	OS	Tertile	All	0.205	0.911	<.001	36	view →
SKCM	DFS	Tertile	II,III,IV	0.206	0.568	.003	30	view →
STAD	OS	Tertile	II,III,IV	0.204	0.586	.005	27	view →
UCS	OS	Tertile	All	0.153	0.687	.019	18	view →
KIRP	OS	Tertile	II,III,IV	0.199	0.771	.030	15	view →
KIRC	DFS	Tertile	All	0.345	0.633	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CYCSP53–CESC (OS)

Open the CESC breakdown →