CYCSP52

Across TCGA pan-cancer cohorts, CYCSP52 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CYCSP52 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CYCSP52 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYCSP52 expression acts as an unfavorable survival marker, although some lineages such as BRCA and STAD show a favorable association.

KIRP, LGG, and BRCA are the cancer types where CYCSP52 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.837	0.955	<.001	56	view →
LGG	DFS	Median	All	0.780	0.882	<.001	33	view →
BRCA	DFS	Median	III,IV	0.573	0.393	.002	30	view →
STAD	OS	Median	IV	0.555	0.211	.001	30	view →
UVM	DFS	Quartile	III,IV	0.172	0.733	.018	20	view →
READ	DFS	Median	III,IV	0.504	0.872	.006	18	view →
PAAD	DFS	Median	II,III,IV	0.569	0.357	.008	17	view →
HNSC	OS	Median	All	0.811	0.721	.019	13	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.843	.008	13	view →
CHOL	DFS	Tertile	III,IV	0.174	0.779	.024	12	view →
PCPG	OS	Quartile	All	0.901	1.000	.005	12	view →
SKCM	DFS	Tertile	II,III,IV	0.189	0.435	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CYCSP52–KIRP (DFS)

Open the KIRP breakdown →