Across TCGA pan-cancer cohorts, CYCSP51 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CYCSP51’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CYCSP51 RNA is repressed in tumor relative to normal tissue. In most cancer types CYCSP51 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC, COAD, and LUAD are the cancer types where CYCSP51 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYCSP51 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.