CYCSP48

Across TCGA patient cohorts, CYCSP48 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,517 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CYCSP48-associated GO terms across cancer lineages are Regulation of double-strand break repair via homologous recombination, Protein quality control for misfolded or incompletely synthesized proteins, and Nuclear membrane organization. Each is linked with CYCSP48 in more than 5 cancer types. Because this analysis shows association rather than direction, both CYCSP48-to-partner and partner-to-CYCSP48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair via homologous recombination grouped by CYCSP48-low versus CYCSP48-high in HNSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYCSP48→partner) and Y-score (partner→CYCSP48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Regulation of double-strand break repair via homologous recombination →	+0.076	+0.015	<.001	.005	3	6
STAD	Protein quality control for misfolded or incompletely synthesized proteins →	+0.073	+0.053	<.001	<.001	3	6
LUSC	Nuclear membrane organization →	+0.072	+0.030	<.001	<.001	3	6
STAD	Ribose phosphate biosynthetic process →	+0.066	+0.046	<.001	<.001	3	6
STAD	Respiratory electron transport chain →	+0.076	+0.089	<.001	<.001	3	5
STAD	Obsolete ubiquitin-dependent ERAD pathway →	+0.070	+0.105	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,517 associations by consensus.

Regulation of double-strand break repair via homologous recombination by CYCSP48 expression — HNSC

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