CYCSP34

Across TCGA pan-cancer cohorts, CYCSP34 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CYCSP34’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where CYCSP34 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CYCSP34 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

STAD, COAD, and THCA are the cancer types where CYCSP34 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYCSP34 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	+0.670	<.001	7	view →
COAD	All	II,III,IV	+0.738	<.001	6	view →
THCA	All	All	−0.507	<.001	6	view →
LUSC	All	All	−0.411	.001	5	view →
LIHC	All	All	+0.455	.001	4	view →
CHOL	Male	All	+2.378	<.001	3	view →
READ	Female	All	+1.882	.012	2	view →
KICH	All	All	−0.546	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CYCSP34–STAD

Open the STAD breakdown →