CYCSP27

Across TCGA pan-cancer cohorts, CYCSP27 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CYCSP27’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CYCSP27 RNA is repressed in tumor relative to normal tissue. In most cancer types CYCSP27 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA and ESCA are the cancer types where CYCSP27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYCSP27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.111	.001	7	view →
ESCA	Female	All	+0.166	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

CYCSP27–THCA

Open the THCA breakdown →