CYCSP25

Across TCGA pan-cancer cohorts, CYCSP25 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated CYCSP25 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher CYCSP25 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CYCSP25 expression acts as an unfavorable survival marker, although some lineages such as ESCA and BRCA show a favorable association.

UVM, LGG, and ACC are the cancer types where CYCSP25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.265	0.699	.003	54	view →
LGG	DFS	Tertile	All	0.645	0.843	<.001	36	view →
ACC	OS	Tertile	All	0.219	0.648	.010	18	view →
THCA	OS	Tertile	II,III,IV	0.557	0.839	.011	15	view →
ESCA	OS	Median	IV	0.698	0.222	.006	12	view →
BRCA	DFS	Tertile	III,IV	0.945	0.862	.029	6	view →
BLCA	DFS	Tertile	III,IV	0.596	0.423	.047	3	view →
HNSC	OS	Tertile	IV	0.623	0.333	.048	3	view →
STAD	OS	Quartile	III,IV	0.219	0.504	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CYCSP25–UVM (OS)

Open the UVM breakdown →