CYCS

Across TCGA patient cohorts, CYCS mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYCS-associated genes across cancer lineages are p62 Lck ligand, Tuberin, and MEK1. Each is linked with CYCS in more than 1 cancer types. Because this analysis shows association rather than direction, both CYCS-to-partner and partner-to-CYCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CYCS-low versus CYCS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYCS→partner) and Y-score (partner→CYCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.514	+3.009	.002	.019	3	1
UCEC	Tuberin →	+0.303	+3.321	.032	.010	3	1
UCEC	MEK1 →	+0.508	+3.169	.008	.019	2	1
UCEC	Notch1 →	+0.224	+3.009	.002	.019	2	1
UCEC	TIGAR →	+0.243	+3.348	.002	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p62 Lck ligand by CYCS expression — UCEC

Explore this box plot interactively →