CYCS

Across TCGA cell cohorts, CYCS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,070 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CYCS-associated GO terms across cancer lineages are Pseudouridine synthesis, mRNA pseudouridine synthesis, and DNA-templated transcription termination. Each is linked with CYCS in more than 13 cancer types. Because this analysis shows association rather than direction, both CYCS-to-partner and partner-to-CYCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pseudouridine synthesis grouped by CYCS-low versus CYCS-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYCS→partner) and Y-score (partner→CYCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Pseudouridine synthesis →	+0.107	+1.342	.001	<.001	3	13
BLOOD_Myeloma	mRNA pseudouridine synthesis →	+0.090	+1.057	.002	.002	2	14
BLOOD_Myeloma	DNA-templated transcription termination →	+0.108	+1.448	<.001	<.001	3	12
BONE	tRNA metabolic process →	+0.071	+0.922	.004	.006	3	12
BONE	Mitochondrial gene expression →	+0.095	+0.971	.004	.006	3	12
BLOOD_Myeloma	Ribosomal large subunit assembly →	+0.120	+1.331	.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,070 associations by consensus.

Pseudouridine synthesis by CYCS expression — OESOPHAGUS

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