CYC1

Across TCGA patient cohorts, CYC1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,154 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CYC1-associated genes across cancer lineages are DSE, FSTL1, and GLIPR1. Each is linked with CYC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CYC1-to-partner and partner-to-CYC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYC1 versus DSE in OV, with a Pearson correlation of -0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYC1→partner) and Y-score (partner→CYC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DSE →	-0.768	-0.717	<.001	<.001	3	7
OV	FSTL1 →	-1.430	-0.725	<.001	<.001	3	7
OV	GLIPR1 →	-0.889	-0.745	.003	<.001	3	7
OV	STX2 →	-0.979	-0.701	<.001	<.001	3	6
BRCA	PKD2 →	-0.768	-0.326	<.001	<.001	3	6
OV	CNRIP1 →	-0.884	-0.704	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,154 associations by consensus.

CYC1 vs DSE — OV

Explore this scatter interactively →