CYC1

Across TCGA patient cohorts, CYC1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYC1-associated genes across cancer lineages are EGFR_pY1068, MSH6, and Notch1. Each is linked with CYC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYC1-to-partner and partner-to-CYC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CYC1-low versus CYC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYC1→partner) and Y-score (partner→CYC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.290	-2.321	.021	.035	3	1
UCEC	MSH6 →	-0.520	-2.999	.001	.035	3	1
UCEC	Notch1 →	+0.194	+3.009	.006	.019	3	1
UCEC	VHL →	-0.792	-3.169	.020	.019	3	1
UCEC	4E-BP1_pT37_T46 →	-0.435	-2.321	.021	.035	2	1
UCEC	Shc_pY317 →	-0.184	-2.321	.015	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR_pY1068 by CYC1 expression — UCEC

Explore this box plot interactively →