CYBC1

Across TCGA pan-cancer cohorts, CYBC1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CYBC1 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CYBC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CYBC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where CYBC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.910	0.612	<.001	20	view →
PDAC	DFS	Quartile	III,IV	0.341	1.000	.016	14	view →
UCEC	DFS	Quartile	All	0.798	1.000	.017	12	view →
COAD	DFS	Median	III,IV	0.899	1.000	.049	6	view →
GBM	DFS	Tertile	All	0.510	0.771	.021	2	view →
CCRCC	DFS	Tertile	III,IV	0.529	0.790	.043	1	view →
LSCC	OS	Quartile	All	0.960	0.786	.009	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CYBC1–HNSC (OS)

Open the HNSC breakdown →