Across TCGA cell cohorts, CYB5RL mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYB5RL-associated genes across cancer lineages are ESX1, DCLK3, and VWC2. Each is linked with CYB5RL in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5RL-to-partner and partner-to-CYB5RL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5RL→partner) and Y-score (partner→CYB5RL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ESX1 →	+0.022	+4.467	.001	.004	3	1
LARGE_INTESTINE	DCLK3 →	+0.026	+4.467	<.001	.004	3	1
LARGE_INTESTINE	VWC2 →	+0.165	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR4A47 →	+0.022	+5.022	<.001	.002	3	1
LARGE_INTESTINE	LBHD2 →	+0.146	+4.273	<.001	.006	3	1
BLOOD_Lymphoma	DEFB103A →	+0.019	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

CYB5RL survival (RNA) · tumor vs normal (RNA) · all CYB5RL data types