CYB5R4

Across TCGA pan-cancer cohorts, CYB5R4 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CYB5R4’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CYB5R4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CYB5R4 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

CCRCC, LUAD, and PDAC are the cancer types where CYB5R4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYB5R4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.373	<.001	12	view →
LUAD	Female	All	−0.173	<.001	8	view →
PDAC	All	All	+0.258	.002	4	view →
HNSC	All	All	+0.120	.006	3	view →
LSCC	All	All	−0.061	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CYB5R4–CCRCC

Open the CCRCC breakdown →