CYB5R3

Across TCGA pan-cancer cohorts, CYB5R3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CYB5R3 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CYB5R3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYB5R3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where CYB5R3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.475	0.893	<.001	61	view →
CCRCC	DFS	Quartile	All	0.873	0.435	.014	22	view →
LUAD	DFS	Quartile	III,IV	0.276	0.707	.005	15	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
UCEC	DFS	Tertile	All	0.775	0.916	.043	4	view →
GBM	DFS	Quartile	All	0.225	0.371	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CYB5R3–LSCC (DFS)

Open the LSCC breakdown →