CYB5R3

Across TCGA patient cohorts, CYB5R3 mutation is significantly associated with the RNA expression of many other genes, with 1,598 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB5R3-associated genes across cancer lineages are TEX33, RNA5SP426, and RNY1P1. Each is linked with CYB5R3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5R3-to-partner and partner-to-CYB5R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX33 grouped by CYB5R3-low versus CYB5R3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5R3→partner) and Y-score (partner→CYB5R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TEX33 →	+0.051	+5.037	<.001	.009	3	2
UCEC	RNA5SP426 →	+0.144	+2.951	.001	.007	3	2
BLCA	RNY1P1 →	+0.419	+5.411	<.001	.005	3	2
BLCA	MIR615 →	+0.565	+5.411	<.001	.005	3	2
UCEC	SYPL1P1 →	+0.101	+2.579	<.001	.001	3	2
UCEC	RNA5SP419 →	+0.577	+2.492	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,598 associations by consensus.

TEX33 by CYB5R3 expression — SKCM

Explore this box plot interactively →