CYB5R3

Across TCGA patient cohorts, CYB5R3 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB5R3-associated genes across cancer lineages are TFRC, ASNS, and 14-3-3_beta. Each is linked with CYB5R3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5R3-to-partner and partner-to-CYB5R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by CYB5R3-low versus CYB5R3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5R3→partner) and Y-score (partner→CYB5R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.586	+3.169	.011	.018	3	2
UCEC	ASNS →	+0.651	+3.321	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.131	-2.432	.002	.018	3	1
UCEC	eIF4E →	+0.216	+3.459	.019	.005	3	1
UCEC	A-Raf_pS299 →	-0.218	-3.321	<.001	.010	3	1
UCEC	Fibronectin →	-0.312	-2.115	.030	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TFRC by CYB5R3 expression — UCEC

Explore this box plot interactively →