CYB5D2

Across TCGA patient cohorts, CYB5D2 mutation is significantly associated with the RNA expression of many other genes, with 530 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB5D2-associated genes across cancer lineages are MIR4727, MIR552, and RNA5SP518. Each is linked with CYB5D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5D2-to-partner and partner-to-CYB5D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4727 grouped by CYB5D2-low versus CYB5D2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5D2→partner) and Y-score (partner→CYB5D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4727 →	+0.675	+5.303	<.001	.006	3	2
LUAD	MIR552 →	+0.286	+7.930	<.001	.008	3	2
LUSC	RNA5SP518 →	+0.358	+7.924	<.001	.008	3	2
UCEC	RNA5SP419 →	+0.545	+2.714	.001	<.001	3	2
UCEC	RNA5SP421 →	+0.570	+2.241	.004	.003	3	2
UCEC	RNA5SP420 →	+0.491	+2.230	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 530 associations by consensus.

MIR4727 by CYB5D2 expression — HNSC

Explore this box plot interactively →