CYB5D2

Across TCGA patient cohorts, CYB5D2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB5D2-associated genes across cancer lineages are Myosin-IIa_pS1943, Myosin-IIa, and ASNS. Each is linked with CYB5D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5D2-to-partner and partner-to-CYB5D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by CYB5D2-low versus CYB5D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5D2→partner) and Y-score (partner→CYB5D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	-0.272	-3.169	.003	.018	3	1
UCEC	Myosin-IIa →	-0.254	-3.155	.003	.018	3	1
UCEC	ASNS →	+0.466	+2.999	.004	.035	3	1
UCEC	4E-BP1 →	+0.246	+2.000	.044	.032	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Myosin-IIa_pS1943 by CYB5D2 expression — UCEC

Explore this box plot interactively →