CYB5D2

Across TCGA cell cohorts, CYB5D2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYB5D2-associated genes across cancer lineages are GRM6, SEPTIN14, and VWC2L. Each is linked with CYB5D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5D2-to-partner and partner-to-CYB5D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRM6 grouped by CYB5D2-low versus CYB5D2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5D2→partner) and Y-score (partner→CYB5D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRM6 →	+0.089	+3.793	<.001	.007	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.009	+3.684	<.001	.006	3	1
LARGE_INTESTINE	VWC2L →	+0.011	+3.930	<.001	.003	3	1
LARGE_INTESTINE	DBX2 →	+0.015	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	OR2J1 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR5M11 →	+0.127	+4.095	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GRM6 by CYB5D2 expression — LARGE_INTESTINE

Explore this box plot interactively →