CYB5D1

Across TCGA patient cohorts, CYB5D1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,166 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible CYB5D1-associated GO terms across cancer lineages are Negative regulation of telomere capping, Smoothened signaling pathway, and Regulation of cilium assembly. Each is linked with CYB5D1 in more than 33 cancer types. Because this analysis shows association rather than direction, both CYB5D1-to-partner and partner-to-CYB5D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of telomere capping grouped by CYB5D1-low versus CYB5D1-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5D1→partner) and Y-score (partner→CYB5D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Negative regulation of telomere capping →	+0.120	+0.647	<.001	<.001	3	34
THYM	Smoothened signaling pathway →	+0.054	+0.934	<.001	<.001	3	34
SCLC	Regulation of cilium assembly →	+0.073	+1.006	<.001	<.001	3	33
SCLC	mRNA export from nucleus →	+0.083	+0.650	<.001	<.001	3	33
THYM	Regulation of smoothened signaling pathway →	+0.053	+0.981	<.001	<.001	3	33
DLBC	Heterochromatin organization →	+0.084	+0.704	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,166 associations by consensus.

Negative regulation of telomere capping by CYB5D1 expression — SCLC

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