CYB561D2

Across TCGA pan-cancer cohorts, CYB561D2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CYB561D2 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher CYB561D2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYB561D2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and DLBC show a favorable association.

KICH, LGG, and LIHC are the cancer types where CYB561D2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.696	0.973	.002	88	view →
LGG	DFS	Median	All	0.672	0.800	<.001	43	view →
LIHC	OS	Median	All	0.612	0.767	<.001	36	view →
ACC	DFS	Median	II,III,IV	0.189	0.670	<.001	33	view →
PAAD	OS	Median	All	0.488	0.288	.009	28	view →
KIRC	DFS	Quartile	III,IV	0.629	0.834	.017	26	view →
UVM	DFS	Quartile	III,IV	0.402	0.852	.013	21	view →
DLBC	OS	Median	All	1.000	0.803	.006	20	view →
BRCA	OS	Tertile	II,III,IV	0.974	0.944	.007	18	view →
MESO	OS	Tertile	IV	0.287	0.818	.006	18	view →
GBM	OS	Tertile	All	0.289	0.524	.008	18	view →
THYM	DFS	Median	All	0.875	0.552	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CYB561D2–KICH (DFS)

Open the KICH breakdown →