CYB561

Across TCGA patient cohorts, CYB561 mutation is significantly associated with the RNA expression of many other genes, with 828 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB561-associated genes across cancer lineages are MIR6894, PLA2G3, and FBXO7. Each is linked with CYB561 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB561-to-partner and partner-to-CYB561 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6894 grouped by CYB561-low versus CYB561-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB561→partner) and Y-score (partner→CYB561) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6894 →	+0.449	+1.981	.008	.007	3	2
UCEC	PLA2G3 →	+0.829	+3.371	.003	.004	3	1
UCEC	FBXO7 →	+0.420	+2.625	.004	.005	3	1
UCEC	POLDIP3 →	+0.537	+2.949	.002	<.001	3	1
UCEC	PPP6R2 →	+0.384	+3.330	.005	.005	3	1
UCEC	AP1B1 →	+0.505	+2.928	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 828 associations by consensus.

MIR6894 by CYB561 expression — UCEC

Explore this box plot interactively →