CYB561

Across TCGA cell cohorts, CYB561 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYB561-associated genes across cancer lineages are ZNF648, NPY2R, and PRAMEF20. Each is linked with CYB561 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB561-to-partner and partner-to-CYB561 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF648 grouped by CYB561-low versus CYB561-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB561→partner) and Y-score (partner→CYB561) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF648 →	+0.060	+3.758	.002	.007	3	1
LARGE_INTESTINE	NPY2R →	+0.004	+3.632	<.001	.003	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
LARGE_INTESTINE	KRTAP7-1 →	+0.040	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ZNF648 by CYB561 expression — LARGE_INTESTINE

Explore this box plot interactively →