CYB561

Across TCGA cell cohorts, CYB561 mutation is significantly associated with the mutation status of many other genes, with 1,375 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYB561-associated genes across cancer lineages are C5orf15, MMP19, and FLRT3. Each is linked with CYB561 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB561-to-partner and partner-to-CYB561 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf15 grouped by CYB561-low versus CYB561-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB561→partner) and Y-score (partner→CYB561) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C5orf15 →	+5.215	+4.159	<.001	<.001	1	2
LARGE_INTESTINE	MMP19 →	+3.630	+3.630	.001	.001	1	2
LARGE_INTESTINE	FLRT3 →	+2.536	+3.504	.001	.001	1	2
LARGE_INTESTINE	ACKR4 →	+3.799	+3.329	.005	.005	1	2
LARGE_INTESTINE	INPP5K →	+3.630	+3.630	.001	.001	1	2
LARGE_INTESTINE	TJAP1 →	+2.407	+2.886	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,375 associations by consensus.

C5orf15 by CYB561 expression — LARGE_INTESTINE

Explore this box plot interactively →