Across TCGA patient cohorts, CXorf66 mutation is significantly associated with the RNA expression of many other genes, with 2,440 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXorf66-associated genes across cancer lineages are SF3B2, WBP1LP6, and FADS1. Each is linked with CXorf66 in more than 3 cancer types. Because this analysis shows association rather than direction, both CXorf66-to-partner and partner-to-CXorf66 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXorf66→partner) and Y-score (partner→CXorf66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SF3B2 →	+0.496	+3.240	.001	.009	3	3
LUAD	WBP1LP6 →	+0.062	+3.912	<.001	.009	3	3
UCEC	FADS1 →	+0.668	+2.431	.001	.001	3	3
UCEC	LTO1 →	+0.254	+1.716	.006	.006	3	3
UCEC	EME1 →	+0.562	+2.403	.001	<.001	3	3
UCEC	BUB1B →	+0.613	+2.403	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,440 associations by consensus.

Exploration

CXorf66 survival (RNA) · tumor vs normal (RNA) · all CXorf66 data types