Across TCGA patient cohorts, CXorf66 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXorf66-associated genes across cancer lineages are ASNS, 14-3-3_beta, and EGFR_pY1068. Each is linked with CXorf66 in more than 2 cancer types. Because this analysis shows association rather than direction, both CXorf66-to-partner and partner-to-CXorf66 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXorf66→partner) and Y-score (partner→CXorf66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.358	+1.807	.008	.025	3	3
UCEC	14-3-3_beta →	-0.115	-2.649	.002	<.001	3	2
UCEC	EGFR_pY1068 →	-0.285	-2.662	.002	<.001	3	2
UCEC	Shc_pY317 →	-0.173	-3.459	.002	.005	3	2
SKCM	beta-Catenin →	+0.692	+3.169	.014	.019	3	1
UCEC	Caspase-8 →	-0.265	-2.502	.004	.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

CXorf66 survival (RNA) · tumor vs normal (RNA) · all CXorf66 data types