Across TCGA patient cohorts, CXorf65 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXorf65-associated genes across cancer lineages are A-Raf_pS299, MEK1, and mTOR_pS2448. Each is linked with CXorf65 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXorf65-to-partner and partner-to-CXorf65 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXorf65→partner) and Y-score (partner→CXorf65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.143	-3.321	.004	.009	3	1
UCEC	MEK1 →	+0.427	+3.459	.005	.005	3	1
UCEC	mTOR_pS2448 →	-0.150	-3.156	.017	.018	3	1
UCEC	Notch1 →	+0.175	+3.469	.003	.002	3	1
UCEC	p27_pT198 →	+0.097	+3.321	.033	.010	3	1
UCEC	p53 →	-0.333	-2.906	.042	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

CXorf65 survival (RNA) · tumor vs normal (RNA) · all CXorf65 data types