Across TCGA pan-cancer cohorts, CXorf49B RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CXorf49B’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CXorf49B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CXorf49B is over-expressed in tumor.
HNSC are the cancer types where CXorf49B tumor–normal differential expression is most reproducible.