CXXC5

Across TCGA pan-cancer cohorts, CXXC5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CXXC5 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CXXC5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CXXC5 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where CXXC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.768	1.000	.002	31	view →
PDAC	OS	Median	II,III,IV	0.171	0.560	.004	18	view →
LUAD	DFS	Quartile	All	0.797	0.331	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CXXC5–LSCC (DFS)

Open the LSCC breakdown →